2018
Identification of Rubisco anxiolytic-like peptides(rALPs) by comprehensive
analysis of spinach green leaf protein digest.
Kimura S, Uchida T, Tokuyama Y, Hosokawa M, Nakato J, Kurabayashi A, Sato
M, Suzuki H, Kanamoto R, Ohinata K.
Biochem Biophys Res Commun. 2018 Nov 10.
Enzymatic digest of whey protein and wheylin-1, a dipeptide released in
the digest, increase insulin sensitivity in an Akt phosphorylation-dependent
manner.
Ogiwara M, Ota W, Mizushige T, Kanamoto R, Ohinata K.
Food Funct. 2018 Sep 19.
Low-fat diet, and medium-fat diets containing coconut oil and soybean oil
exert different metabolic effects in untrained and treadmill-trained mice.
Manio MC, Matsumura S, Inoue K.
J int Soc Sports Nutr.2018 Jun 18.
Orally active anti-hypertensive peptides found based on enteroendocrine
cell responses to a dipeptide library.
Sasai M, sun X, Okuda C, Nakato J, Kanamoto R, Ohinata K.
Biochem Biophys Res Commun.2018 Jun 25.
Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor.
Karim MR, Yanagawa A, Ohinata K.
Biochem Biophys Res Commun. 2018 May 15.
2017
A Novel Anti-Hypertensive Peptide Identified in Thermolysin-Digested Rice
Bran.
Naohisa Shobako, Yutaro Ogawa, Atsushi Ishikado, Kayo Harada, Etsuko Kobayashi,
Hirohisa Suido, Takeshi Kusakari, Mariko Maeda, Makoto Suwa, Motonobu Matsumoto,
Ryuhei Kanamoto, Kousaku Ohinata.
Mol Nutr Food Res. 2017 Dec 27.
Characterization of soy-deprestatin, a novel orally-active decapeptide that exerts antidepressant-like effects via gut-brain communication.
Mori Y, Asakura S, Yamamoto A, Odagiri S, Yamada D, Sekiguchi M, Wada K,
Sato M, Kurabayashi A, Suzuki H, Kanamoto R, Ohinata K.
FASEB J. 2017 Sep 27.
L-Ornithine and L-lysine stimulate gastrointestinal motility via transient
receptor potential vanilloid 1.
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto
T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K. Mol Nutr Food
Res. 2017 Jul 18
Lacto-ghrestatin, a novel bovine milk-derived peptide, suppresses ghrelin
secretion.
Aoki H, Nakato J, Mizushige T, Iwakura H, Sato M, Suzuki H, Kanamoto R,
Ohinata K. FEBS Lett. 2017 Jul;591(14):2121-2130.
l-Ornithine stimulates growth hormone release in a manner dependent on
the ghrelin system.
Ho YY, Nakato J, Mizushige T, Kanamoto R, Tanida M, Akiduki S, Ohinata
K. Food Funct. 2017 Jun 1;8(6):2110-2114.
Rational identification of a novel soy-derived anxiolytic-like undecapeptide
acting via gut-brain axis after oral administration.
Ami Ota, Akane Yamamoto, Saeko Kimura, Yukiha Mori, Takafumi Mizushige,
Yoshiki Nagashima, Masaru Sato, Hideyuki Suzuki, Saori Odagiri, Daisuke
Yamada, Masayuki Sekiguchi, Keiji Wada, Ryuhei Kanamoto, Kousaku Ohinata
Neurochemistry International. Volume 105 May 2017 Pages 51-57
2016
Soy-ghretropin, a novel ghrelin-releasing peptide derived from soy protein
Junya Nakato, Hayato Aoki, Hiroshi Iwakura, Hideyuki Suzuki, Ryuhei Kanamoto, Kousaku Ohinata
FEBS Letters.16 August 2016 Pages 2681-2689
2015
Brain-specific natriuretic peptide receptor-B deletion attenuates high-fat diet-induced visceral and hepatic lipid deposition in mice.
Yamashita Y, Yamada-Goto N, Katsuura G, Ochi Y, Kanai Y, Miyazaki Y, Kuwahara K, Kanamoto N, Miura M, Yasoda A, Ohinata K, Inagaki N, Nakao K.
Peptides. 2016 Mar 25. (16)30049-3.Epub 2016 Mar 14
A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice.
Ayabe T, Mizushige T, Ota W, Kawabata F, Hayamizu K, Han L, Tsuji T, Kanamoto R, Ohinata K.
Food Funct. 2015 Aug;6(8):2749-57.Epub 2015 Jul 8.
Antidepressant-like effect of food-derived pyroglutamyl peptides in mice.
Yamamoto Y, Mizushige T, Mori Y, Shimmura Y, Fukutomi R, Kanamoto R, Ohinata K.
Neuropeptides. 2015 Jun;51:25-9. Epub 2015 Apr 22.
2014
Orally administered δ opioid agonist peptide rubiscolin-6 stimulates food
intake in aged mice with ghrelin resistance.
Miyazaki Y, Kaneko K, Iguchi S, Mizushige T, Kanamoto R, Yoshikawa M, Shimizu T, Ohinata K.
Mol Nutr Food Res. 2014 Oct;58(10):2046-52.Epub 2014 Jul 22.
δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice.
Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K.
Am J Physiol Regul Integr Comp Physiol. 2014 Feb 15;306(4):R265-72.Epub
2014 Jan 8.
Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities.
Kontani N, Omae R, Kagebayashi T, Kaneko K, Yamada Y, Mizushige T, Kanamoto
R, Ohinata K.
Mol Nutr Food Res. 2014 Feb;58(2):359-64.Epub 2013 Sep 17.
Identification of novel β-lactoglobulin-derived peptides, wheylin-1 and -2, having anxiolytic-like activity in mice.
Yamada A, Mizushige T, Kanamoto R, Ohinata K.
Mol Nutr Food Res. 2014 Feb;58(2):353-8. Epub 2013 Sep 3.
2013
Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.
Mizushige T, Sawashi Y, Yamada A, Kanamoto R, Ohinata K.
FASEB J. 2013 Apr 11.
Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice.
Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K.
Neurosci Lett. 2013 Apr 6.
2012
Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide.
Kaneko K, Yoshikawa M, Ohinata K.
Neuropeptides. 2012 Dec;46(6):353-7. doi: 10.1016/j.npep.2012.10.003. Epub 2012 Nov 9.
Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.
Kagebayashi T, Kontani N, Yamada Y, Mizushige T, Arai T, Kino K, Ohinata K.
Mol Nutr Food Res. 2012 Sep;56(9):1456-63. doi: 10.1002/mnfr.201200168. Epub 2012 Aug 1.
Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice.
Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K.
Mol Nutr Food Res. 2012 Aug;56(8):1315-23. doi: 10.1002/mnfr.201200155. Epub 2012 Jun 20.
Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity.
Oda A, Kaneko K, Mizushige T, Lazarus M, Urade Y, Ohinata K.
J Neurochem. 2012 May 4
Complement C5a exhibits anxiolytic-like activity via the prostaglandin D2-DP1 receptor system coupled to adenosine A2A and GABAA receptors.
Miyamoto C, Yoshida M, Yoshikawa M, Mizushige T, Ohinata K.
Prostaglandins Other Lipid Mediat. 2012 May;98(1-2):17-22.
2011
Soymorphin-5, a soy-derived μ opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KK-Ay mice.
Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K.
Am J Physiol Endocrinol Metab. 2011 Nov 29.
β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS(2) receptor via activation of dopamine D(1) receptor in mice.
Hou IC, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K.
J Neurochem. 2011 Nov;119(4):785-90. doi: 10.1111/j.1471-4159.2011.07472.x. Epub 2011 Oct 10.
Central PGE2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors.
Suzuki C, Miyamoto C, Furuyashiki T, Narumiya S, Ohinata K.
FEBS Lett. 2011 Jul 21;585(14):2357-62. Epub 2011 Jun 17.
Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice.
Yamada Y, Ohinata K, Lipkowski AW, Yoshikawa M.
Peptides. 2011 Feb;32(2):281-5. Epub 2010 Dec 1.
2010
Orally
administered soymorphins, soy-derived opioid peptides, suppress feeding and
intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B)
systems.
Kaneko K, Iwasaki M, Yoshikawa M, Ohinata K.
Am
J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G799-805. Epub 2010
Jul 8.
Rapakinin, an anti-hypertensive peptide derived from rapeseed protein, dilates mesenteric artery of spontaneously hypertensive rats via the prostaglandin IP receptor followed by CCK(1) receptor.
Yamada Y, Iwasaki M, Usui H, Ohinata K, Marczak ED, Lipkowski AW, Yoshikawa M.
Peptides. 2010 May;31(5):909-14. Epub 2010 Feb 25.
Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration
via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice.
Kanegawa N, Suzuki C, Ohinata K.
FEBS Lett. 2010 Feb 5;584(3):599-604. Epub 2009 Dec 23.
2009
beta-Lactotensin derived from bovine beta-lactoglobulin suppresses food intake via the CRF system followed by the CGRP system in mice..
Hou IC, Yoshikawa M, Ohinata K.
Peptides. 2009 Dec;30(12):2228-32. Epub 2009 Aug 29.
Complement C5a stimulates food intake via a prostaglandin D(2)- and neuropeptide Y-dependent mechanism in mice.
Ohinata K, Takagi K, Biyajima K, Kaneko K, Miyamoto C, Asakawa A, Eguchi
N, Urade Y, Inui A, Yoshikawa M.
Prostaglandins Other Lipid Mediat. 2009 Dec;90(3-4):81-4. Epub 2009 Oct 1.
Orally
administered novokinin, an angiotensin AT(2) receptor agonist, suppresses food
intake via prostaglandin E(2)-dependent mechanism in mice.
Ohinata K, Fujiwata Y, Shingo F, Masaru I, Masatsugu H,
Yoshikawa M.
Peptides. 2009
Jun;30(6):1105-8. Epub 2009 Mar 24.
2008
Central
prostaglandin D(2) stimulates food intake via the neuropeptide Y system in
mice.
Ohinata K, Takagi K, Biyajima K, Fujiwara Y, Fukumoto S, Eguchi
N, Urade Y, Asakawa A, Fujimiya M, Inui A, Yoshikawa M.
FEBS Lett.
2008 Mar 5;582(5):679-84. Epub 2008 Feb 5.
Hypotensive
activity of novokinin, a potent analogue of ovokinin(2-7), is mediated by
angiotensin AT(2) receptor and prostaglandin IP receptor.
Yamada Y, Yamauchi D, Usui H, Zhao H, Yokoo M, Ohinata K, Iwai
M, Horiuchi M, Yoshikawa M.
Peptides. 2008
Mar;29(3):412-8. Epub 2007 Dec 4.
2007
2006
2005以前
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